Palanki, Moorthy S. : rechercher sur Z-Library

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1

Structure–Activity Relationship Studies of Ethyl 2-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate: An Inhibitor of AP-1 and NF-κB Mediated Gene Expression

Moorthy S.S. Palanki, Leah M. Gayo-Fung, Graziella I. Shevlin, Paul Erdman, Mark Sato, Mark Goldman, Lynn J. Ransone, Cheryl Spooner

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 163 KB

english, 2002

2

Discovery of 3,3‘-(2,4-Diaminopteridine-6,7-diyl)diphenol as an Isozyme-Selective Inhibitor of PI3K for the Treatment of Ischemia Reperfusion Injury Associated with Myocardial Infarction

Palanki, Moorthy S. S., Dneprovskaia, Elena, Doukas, John, Fine, Richard M., Hood, John, Kang, Xinshan, Lohse, Dan, Martin, Michael, Noronha, Glenn, Soll, Richard M., Wrasidlo, Wolfgang, Yee, Shiyin,

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 500 KB

english, 2007

3

ChemInform Abstract: Novel Inhibitors of AP-1 and NF-ϰB Mediated Gene Expression: Structure—Activity Relationship Studies of Ethyl 4-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino] -2-(trifluoromethyl)pyrimidine-5-carboxylate.

Moorthy S. S. Palanki, Paul E. Erdman, Anthony M. Manning, Arnold Ow, Lynn J. Ransone, Cheryl Spooner, Carla Suto, Mark Suto

Journal:

Année:

2000

Fichier:

PDF, 34 KB

2000

4

Structure—Activity Relationship Studies of Ethyl 2-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino] -4-(trifluoromethyl)pyrimidine-5-carboxylate: An Inhibitor of AP-1 and NF-ϰB Mediated Gene Expression.

Moorthy S. S. Palanki, Leah M. Gayo-Fung, Graziella I. Shevlin, Paul Erdman, Mark Sato, Mark Goldman, Lynn J. Ransone, Cheryl Spooner

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 87 KB

english, 2003

5

The Design and Synthesis of Novel Orally Active Inhibitors of AP-1 and NF-ϰB Mediated Transcriptional Activation. SAR of in vitro and in vivo Studies.

Moorthy S. S. Palanki, et al. et al.

Journal:

Année:

2004

Fichier:

PDF, 94 KB

2004

6

The design and synthesis of novel orally active inhibitors of AP-1 and NF-κB mediated transcriptional activation. SAR of In vitro and In vivo studies

Moorthy S.S. Palanki, Paul E. Erdman, Minghuan Ren, Mark Suto, Brydon L. Bennett, Anthony Manning, Lynn Ransone, Cheryl Spooner, Sonal Desai, Arnie Ow, Ryuichi Totsuka, Peter Tsao, Wataru Toriumi

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 169 KB

english, 2003

7

The design and preliminary structure–activity relationship studies of benzotriazines as potent inhibitors of Abl and Abl-T315I enzymes

Jianguo Cao, Richard Fine, Colleen Gritzen, John Hood, Xinshan Kang, Boris Klebansky, Dan Lohse, Chi Ching Mak, Andrew McPherson, Glenn Noronha, Moorthy S.S. Palanki, Ved P. Pathak, Joel Renick, Richa

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2007

8

Novel inhibitors of AP-1 and NF-κB mediated gene expression: structure–activity relationship studies of ethyl 4-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carboxylate

Moorthy S.S Palanki, Paul E Erdman, Anthony M Manning, Arnold Ow, Lynn J Ransone, Cheryl Spooner, Carla Suto, Mark Suto

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 156 KB

english, 2000

9

Use of transferred nuclear overhauser effects to determine the conformation of 1-(3,4-dichlorophenyl)-2-aminopropane when bound to the active site of phenylethanolamine N-methyltransferace (PNMT)

Gary L. Grunewald, Moorthy S.S. Palanki, David Vander Velde

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 263 KB

english, 1992

10

Solution-phase parallel synthesis using ion-exchange resins

Mark J. Suto, Leah M. Gayo-Fung, Moorthy S.S. Palanki, Robert Sullivan

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 503 KB

english, 1998

11

Evaluation of functional Analogs of CC-1065 and the Duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (C2BI) alkylation subunit

Dale L. Boger, Douglas S. Johnson, Moorthy S.S. Palanki, Paul A. Kitos, Jiyoung Chang, Paul Dowell

Journal:

Bioorganic & Medicinal Chemistry

Année:

1993

Langue:

english

Fichier:

PDF, 1.18 MB

english, 1993

12

Inhibitors of NF-κB and AP-1 Gene Expression: SAR Studies on the Pyrimidine Portion of 2-Chloro-4-trifluoromethylpyrimidine-5-[N-(3‘,5‘-bis(trifluoromethyl)phenyl)carboxamide]

Palanki, Moorthy S. S., Erdman, Paul E., Gayo-Fung, Leah M., Shevlin, Graziella I., Sullivan, Robert W., Goldman, Mark E., Ransone, Lynn J., Bennett, Brydon L., Manning, Anthony M., Suto, Mark J.

Journal:

Journal of Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 117 KB

english, 2000

13

Development of novel linkers to conjugate pharmacophores to a carrier antibody

Moorthy S.S. Palanki, Abhijit Bhat, Rodney W. Lappe, Bin Liu, Bryan Oates, John Rizzo, Nebojsa Stankovic, Curt Bradshaw

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 731 KB

english, 2012

14

Development of a long acting human growth hormone analog suitable for once a week dosing

Palanki, Moorthy S.S., Bhat, Abhijit, Bolanos, Ben, Brunel, Florence, Del Rosario, Joselyn, Dettling, Danielle, Horn, Mark, Lappe, Rodney, Preston, Ryan, Sievers, Annette, Stankovic, Nebojsa, Woodnut,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 593 KB

english, 2013

15

ONE-STEP SYNTHESIS OF TRIFLUOROMETHYL- AND OF METHOXY-SUBSTITUTED BENZYNE PRECURSORS

Grunewald, Gary, Kolar, Aldean, Palanki, Moorthy, Paradkar, Vidyadhar, Reitz, Thomas, Sall, Daniel

Journal:

Organic Preparations and Procedures International

Année:

1990

Langue:

english

Fichier:

PDF, 352 KB

english, 1990

16

Functional analogs of CC-1065 and the duocarmycins incorporating the 9a-(chloromethyl)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (C2BI) alkylation subunit: synthesis and preliminary DNA alkylation studies

Boger, Dale L., Palanki, Moorthy S. S.

Journal:

Journal of the American Chemical Society

Année:

1992

Langue:

english

Fichier:

PDF, 2.05 MB

english, 1992

17

Development of novel benzotriazines for drug discovery

Palanki, Moorthy SS, Cao, Jianguo, Chow, Chun P, Dneprovskaia, Elena, Mak, Chi Ching, McPherson, Andrew, Pathak, Ved P, Renick, Joel, Soll, Richard, Zeng, Binqi, Noronha, Glenn

Journal:

Expert Opinion on Drug Discovery

Année:

2009

Langue:

english

Fichier:

PDF, 610 KB

english, 2009

18

2-Chloro-4-(trifluoromethyl)pyrimidine-5- N -(3‘,5‘-bis(trifluoromethyl)phenyl)- carboxamide: A Potent Inhibitor of NF-κB- and AP-1-Mediated Gene Expression Identified Using Solution-Phase Combinatorial Chemistry

Sullivan, Robert W., Bigam, Colin G., Erdman, Paul E., Palanki, Moorthy S. S., Anderson, David W., Goldman, Mark E., Ransone, Lynn J., Suto, Mark J.

Journal:

Journal of Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 126 KB

english, 1998

19

Immunospecific Reduction of Antioligonucleotide Antibody-Forming Cells with a Tetrakis-oligonucleotide Conjugate (LJP 394), a Therapeutic Candidate for the Treatment of Lupus Nephritis

Jones, David S., Barstad, Paul A., Feild, Mark J., Hachmann, John P., Hayag, Merle S., Hill, Kenneth W., Iverson, G. Michael, Livingston, Douglas A., Palanki, Moorthy S.

Journal:

Journal of Medicinal Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 1.27 MB

english, 1995

20

Development of Prodrug 4-Chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl Benzoate (TG100801): A Topically Administered Therapeutic Candidate in Clinical Trials for the Treatment of Age-Related Macular Degeneration

Palanki, Moorthy S. S., Akiyama, Hideo, Campochiaro, Peter, Cao, Jianguo, Chow, Chun P., Dellamary, Luis, Doukas, John, Fine, Richard, Gritzen, Colleen, Hood, John D., Hu, Steven, Kachi, Shu, Kang, Xi

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 669 KB

english, 2008

21

Interleukin-2 inhibitors in autoimmune disease

Palanki, Moorthy SS, Manning, Anthony M

Journal:

Expert Opinion on Therapeutic Patents

Année:

1999

Langue:

english

Fichier:

PDF, 150 KB

english, 1999

22

Inhibitors of AP-1 and NF-κB Mediated Transcriptional Activation: Therapeutic Potential in Autoimmune Diseases and Structural Diversity

Palanki, Moorthy

Journal:

Current Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 126 KB

english, 2002

23

Inhibition of Nuclear Factor-κB in T Cells Suppresses Lung Fibrosis

Fujimoto, Hajime, D'Alessandro-Gabazza, Corina N., Palanki, Moorthy S. S., Erdman, Paul E., Takagi, Takehiro, Gabazza, Esteban C., Bruno, Nelson E., Yano, Yutaka, Hayashi, Tatsuya, Tamaki, Shigenori,

Journal:

American Journal of Respiratory and Critical Care Medicine

Année:

2007

Langue:

english

Fichier:

PDF, 1.82 MB

english, 2007

24

The AP-1/NF-κB double inhibitor SP100030 can revert muscle wasting during experimental cancer cachexia

Moore-Carrasco, Rodrigo, Busquets, Sílvia, Almendro, Vanessa, Palanki, Moorthy, López-Soriano, Francisco, Argilés, Josep

Journal:

International Journal of Oncology

Année:

2007

Langue:

english

Fichier:

PDF, 156 KB

english, 2007